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What is DMT?

DMT is the abbreviation for dimethyltryptamine. It is a naturally occurring hallucinogenic substance. DMT is produced in a number of animals, plants, and in the human organism as a metabolic product.

The chemical structure of DMT bears a close resemblance to the neurotransmitter serotonin, as well as to psilocybin, the hallucinogenic compound found in magic mushrooms. 

DMT develops its hallucinogenic effect in particular by activating serotonin receptors.

Plant components containing DMT are used, for example, in South America to produce the ayahuasca drink, which is drunk by the indigenous people of the Amazon basin as part of religious ceremonies. 

In Australia, DMT-containing plants are also used by the Aborigines for ritual purposes. DMT, used as an intoxicant in Western countries, is obtained from plant components using chemical processes and is usually smoked.

Effects of DMT

DMT has a hallucinogenic effect. Perception changes and acoustic and visual hallucinations are possible. Users also report increased self-awareness.

Physiologically, DMT has a slightly stimulating effect and leads to an increase in heart rate and blood pressure.

The duration of action of DMT depends on whether the drug is smoked or taken orally. 

When consumed orally, for example in the form of the ayahuasca drink, the effect only occurs after about 45 minutes and lasts about four hours. 

On the other hand, if the DMT is smoked, the effects will kick in after about a minute, peak after two to five minutes, and be completely gone after about 20 to 60 minutes.

Risks of DMT

Drinking DMT as ayahuasca can result in nausea, vomiting, and diarrhea. Smoked DMT often causes coughing fits and has a rather unpleasant taste. 

According to surveys of users, frightening experiences during intoxication up to a horror trip are the most common negative consequences of use.

As with other hallucinogenic drugs, the effect is not only a consequence of the dosage of the substance but also depends on one’s own condition and the context, i.e. the environment and the people involved.

Due to the massive influence on the serotonin system, the consumption of DMT, especially when taking certain medications at the same time, can result in serotonin syndrome.

 A very high dose of DMT can therefore be fatal. However, the critical amount is about 20 times the dose normally consumed. 

Since the purity of the predominantly illegally procured DMT is usually not guaranteed, there is always the danger of consuming other, possibly toxic components.

DMT, which is naturally synthesized in the human body, is also suspected of being involved in the development of psychotic symptoms.

Among other things, the hallucinogenic effects of DMT are similar to those of LSD. High concentrations of DMT in the urine were also measured in people with acute, untreated psychosis – similar to people who had consumed the DMT-containing drink ayahuasca immediately before.

However, the role of DMT in the development of psychoses has not yet been thoroughly investigated.